EFFECTS OF JUICE AND SEED EXTRACT OF POMEGRANATE ON OXIDATIVE STRESS, INFLAMMATION, AND PHOSPHORYLATION OF ERK1/2 IN PARAQUAT-INDUCED ACUTE LUNG INJURY IN MICE
نویسندگان
چکیده
Pulmonary fibrosis is considered the most distinctive feature of paraquat (PQ) poisoning. Inflammation and oxidative stress play crucial roles in pathogenesis PQ-induced pulmonary fibrosis. The current study was designed to assess efficacy pomegranate juice (PJ) seed extract (PSE) supplementation against a mouse model. Male mice (Mus musculus) were randomly divided into four experimental groups (n=8). Group 1 (control group) received 0.9% saline only; group 2 single intraperitoneal injection PQ (30 mg/kg); 3 4 daily treated with PJ (5 mL, 1:40 dilution) or PSE (500 mg/kg body weight, suspended distilled water), respectively, by gavage one week before injection, then continued for weeks. increased significantly levels hydroxproline, reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX4), nitric oxide (NO), malondialdehyde (MDA), extracellular signal-regulated kinase 1/2 (ERK1/2) lung tissue compared control group. Furthermore, interleukins (IL-6 IL-17), transforming growth factor (TGF)-β1, CC chemokine ligand (CCL2) elevated due injection. Administration alleviated markedly biochemical alterations caused Additionally, decreased IL-6, IL-17, TGF-β1, CCL2, as well phosphorylated (p)-ERK1/2, PQ-treated mice. In conclusion, administration attenuated effectively injury modulating inflammation, stress,
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ژورنال
عنوان ژورنال: Egyptian Journal of Zoology
سال: 2021
ISSN: ['1110-6344', '2682-3160']
DOI: https://doi.org/10.21608/ejz.2021.55441.1048